Adequate calcium ions in the plasma are required in all phases of many of blood coagulation, and blood will not clot in the absent of calcium. A number of blood proteins, called congratulation factors require Ca2+ ions for activity.
This mineral is essential for the formation of fibrin, the fibrous protein that makes up the structure of blood clots.
In most instances, the calcium binding sites appear to stabilize the fold of proteins but calcium ions may also directly involved in enzymes activation, enzyme –cofactor and domain-domain interaction, as well as in membrane binding.
Blood clot formed at the end of coagulation process is composed of a meshwork of fibrin threads running in all directions along who entrapped blood cells, platelets and plasma.
Calcium role in blood coagulation
