Copper plays a key role in the biosynthesis of the extracellular matrix proteins, collagen and elastin, through its function as a cofactor for the enzyme lysyl oxidase.
Lysyl is a secreted enzyme and it catalyzes cross-linking of collagen, which is necessary for proper collagen formation and integrity of all connective tissue.
Copper ion is being located at its active site. Since lysyl oxidase is a copper-dependent enzyme, impaired cross-linking can occur as a result of copper deficiency.
Inhibition of lysyl oxidase has profound effects on the strength of bone and elastic tissue.
Thus, copper is essential for formation and maintenance connective tissue and skeletal mineralization.
Copper and formation of collagen
